BenzEFoam Study Result
Onset Therapeutics, a specialty pharmaceutical company focused on dermatology, today announced that positive data on the reduction of the acne-causing bacteria Propionibacterium acnes with BenzEFoam (benzoyl peroxide) 5.3% Emollient Foam was presented at a poster session during the Fall Clinical Dermatology Conference in Las Vegas, October 15 – 18th. The results were from an investigator-initiated study by James J. Leyden, MD, Emeritus Professor of Dermatology at the University of Pennsylvania School of Medicine, assessing BenzEFoam Emollient Foam, the first prescription foam formulation of benzoyl peroxide, and a commercially available benzoyl peroxide 8% wash in patients with P. acnes colonization on their backs.
As an acne treatment, benzoyl peroxide works primarily through its potent antibacterial effect. In previous studies of patients with P. acnes colonization on their faces, benzoyl peroxide has demonstrated a 1.0 to 2.0 logarithmic reduction (equivalent to a 90% to 99% reduction) of P. acnes. Prior to this study, no data was available that specifically examined P. acnes reduction on the back with benzoyl peroxide. This five-week, open-label, crossover study included 20 subjects (>18 years old) with P. acnes colonization on their backs (>10,000 colonies per cm2).
The study results demonstrated that total P. acnes colony counts were reduced by >99% after 2 weeks of treatment with BenzEFoam; P. acnes were reduced 1.9 log after one week of treatment and by 2.1 log after two weeks of treatment with BenzEFoam. In contrast, the benzoyl peroxide 8% wash did not reduce P. acnes counts at all after two full weeks of treatment.
“The foam formulation of benzoyl peroxide clearly was effective in reducing P. acnes counts on the back to the level associated with a therapeutic effect when it was applied in our study center,” said Dr. Leyden.
“BenzEFoam Emollient Foam is effective in reducing P. acnes on the back and is easy to spread over broad surface areas when acne presents on the chest, back, and shoulders,” said Doug Abel, General Manager of Onset Therapeutics. “Wash-off formulations of benzoyl peroxide are commonly utilized for the treatment of acne on the trunk, due to patient convenience of application in the shower. However, the results of this study may cause a clinician to reconsider that approach and, in turn, increase their use of a leave-on treatment, such as BenzEFoam™, which is specifically formulated for the treatment of body acne.”
Both treatments were well tolerated by the study subjects. Neither treatment caused skin dryness, redness, scaling, or burning and neither treatment resulted in any patients discontinuing from the study.
BenzEFoam is indicated for the topical treatment of mild to moderate acne vulgaris and was designed for patients experiencing acne symptoms on their backs, shoulders, and chests. This study was supported by a grant from Onset Therapeutics.
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